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Tumor cells can co-opt the pro-migratory activity of chemokines and their cognate G protein-coupled receptors GPCRs to metastasize to regional lymph nodes or distant organs. Indeed, the migration toward SDF-1 stromal cell-derived factor-1 of tumor cells bearing CXCR4 [chemokine C-X-C motif receptor 4] has been implicated in the lymphatic and organ-specific metastasis of various human malignancies. Elucidating the mechanisms by which breast cancer cells spread from their primary sites to distant organs may identify therapeutic targets to prevent metastasis and is thus an area of intense investigation.

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The branch of zoology that studies sponges is known as spongiology. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervousdigestive or circulatory systems.

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